{"id":30404,"date":"2026-08-24T06:00:00","date_gmt":"2026-08-24T10:00:00","guid":{"rendered":"https:\/\/okdiario.com\/metabolic\/en\/?p=30404"},"modified":"2026-08-23T22:05:30","modified_gmt":"2026-08-24T02:05:30","slug":"nazareth-castellanos-neuroscientist-the-neurons-that-activate-in-silence-help-clean-the-brain-calm-the-nervous-system-and-bring-the-mind-back-to-balance","status":"publish","type":"post","link":"https:\/\/okdiario.com\/metabolic\/en\/psychology\/nazareth-castellanos-neuroscientist-the-neurons-that-activate-in-silence-help-clean-the-brain-calm-the-nervous-system-and-bring-the-mind-back-to-balance-30404\/","title":{"rendered":"Nazareth Castellanos, neuroscientist: the neurons that activate in silence help clean the brain, calm the nervous system and bring the mind back to balance"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Traffic outside your window, a phone buzzing on the table, music playing in the kitchen, another video autoplaying before the last one finishes. Modern life rarely gives the nervous system a truly quiet moment.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Spanish neuroscientist Nazareth Castellanos, a senior researcher at Nirakara Lab at Complutense University of Madrid, recently made the case that even short breaks from noise and visual stimulation might help the brain settle down.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cThere are neurons that fire when we hear something, and neurons that fire when there is silence,\u201d she said in a February 2026 radio interview, translated from Spanish.<\/p>\n\n\n\n<div class=\"gb-element-a00da4e5\">\n<div><div class=\"gb-looper-46613eed\">\n<div class=\"gb-loop-item gb-loop-item-a8390598 post-30409 post type-post status-publish format-standard has-post-thumbnail hentry category-sports resize-featured-image\">\n<h3 class=\"gb-text gb-text-24a51617\">Read More: <a href=\"https:\/\/okdiario.com\/metabolic\/en\/sports\/alvaro-puche-personal-trainer-walking-does-nothing-for-your-health-it-is-one-of-the-laziest-and-least-useful-forms-of-movement-there-is-30409\/\">Alvaro Puche, personal trainer: &#8216;Walking does nothing for your health, it is one of the laziest and least useful forms of movement there is&#8217;<\/a><\/h3>\n<\/div>\n<\/div><\/div>\n<\/div>\n\n\n\n<p class=\"wp-block-paragraph\">What makes her message so appealing is how simple it sounds. A few quiet minutes might offer <a href=\"https:\/\/okdiario.com\/metabolic\/en\/psychology\/gustavo-deco-neuroscientist-a-stressed-brain-is-in-survival-mode-a-happy-one-in-learning-mode-and-the-reason-explains-why-you-forget-28852\/\">short-term calm<\/a>. But here is the catch: the strongest laboratory evidence behind the broader claim actually comes from mice, not people, and it never even measured the brain\u2019s waste-clearing system.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What the mouse study found<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">A research team led by Imke Kirste compared young female mice exposed to ordinary animal-house noise, white noise, mouse pup calls, adapted Mozart music, or complete silence. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The animals spent two hours a day in their assigned condition, and the investigators examined cell growth in the hippocampus, a brain area involved in learning and memory.<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"1800\" height=\"1013\" src=\"https:\/\/okdiario.com\/metabolic\/en\/wp-content\/uploads\/2026\/08\/nazareth-castellanos-neuroscientist-silence-brain-neurons-1.jpg\" alt=\"A calm person sitting quietly with eyes closed, enjoying a peaceful moment of mental rest.\" class=\"wp-image-30406\" srcset=\"https:\/\/okdiario.com\/metabolic\/en\/wp-content\/uploads\/2026\/08\/nazareth-castellanos-neuroscientist-silence-brain-neurons-1.jpg 1800w, https:\/\/okdiario.com\/metabolic\/en\/wp-content\/uploads\/2026\/08\/nazareth-castellanos-neuroscientist-silence-brain-neurons-1-300x169.jpg 300w, https:\/\/okdiario.com\/metabolic\/en\/wp-content\/uploads\/2026\/08\/nazareth-castellanos-neuroscientist-silence-brain-neurons-1-768x432.jpg 768w, https:\/\/okdiario.com\/metabolic\/en\/wp-content\/uploads\/2026\/08\/nazareth-castellanos-neuroscientist-silence-brain-neurons-1-1536x864.jpg 1536w, https:\/\/okdiario.com\/metabolic\/en\/wp-content\/uploads\/2026\/08\/nazareth-castellanos-neuroscientist-silence-brain-neurons-1-150x84.jpg 150w\" sizes=\"auto, (max-width: 1800px) 100vw, 1800px\" \/><figcaption class=\"wp-element-caption\">Neuroscientist Nazareth Castellanos highlights how quiet moments and low-stimulation breaks help calm the nervous system and restore mental balance.<\/figcaption><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">This process has a name: adult neurogenesis. In plain terms, it just means new nerve cells forming in the brain of a <a href=\"https:\/\/okdiario.com\/metabolic\/en\/health\/a-growing-body-of-research-suggests-alzheimers-might-quietly-begin-somewhere-you-would-never-expect-deep-inside-your-own-gut-29587\/\">fully grown animal<\/a>. After three days, several of the conditions boosted the number of precursor cells, early-stage cells that can eventually turn into full neurons.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">But here is where it gets interesting. After seven days, however, only the silence group still showed a significant increase in labeled cells and a greater absolute number of immature new neurons. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">It was first published online back on December 1, 2013, and later appeared in the journal\u2019s 2015 volume, so this is not a newly completed experiment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">A surprising reason silence may have worked<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Here is the twist nobody expects. The researchers did not actually conclude that silence necessarily relaxed the mice. Instead, they suspected the opposite might be true: total silence may have felt strange and altering to the mice, precisely because near-total quiet almost never happens naturally.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">And that detail matters a lot, because this study gets repeated constantly as proof that silence\u201cregenerates\u201d the human brain. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In reality, the experiment showed an association between a highly controlled quiet condition and early cell development in mice, but it did not test mood, anxiety, memory improvement, or whether those cells produced lasting health benefits.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">The brain remains active without sound<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Silence doesn&#8217;t mean that the brain is switching off. In a <a href=\"https:\/\/www.jneurosci.org\/content\/26\/1\/273\" target=\"_blank\" rel=\"noopener\">human imaging study<\/a>, 11 adults were asked to listen for a faint sound during periods of silence, and parts of their auditory cortex actually lit up while they waited. Areas of the brain tied to attention got involved too.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">That finding supports a more careful version of the neuroscientist\u2019s point. When sound disappears, the brain can keep monitoring and predicting, and other animal work has found neurons responding when an expected tone is omitted.<\/p>\n\n\n\n<div class=\"gb-element-100d3882\">\n<div><div class=\"gb-looper-075a02c8\">\n<div class=\"gb-loop-item gb-loop-item-5588b049 post-30393 post type-post status-publish format-standard has-post-thumbnail hentry category-health resize-featured-image\">\n<h3 class=\"gb-text gb-text-562c31da\">Read More: <a href=\"https:\/\/okdiario.com\/metabolic\/en\/health\/sara-marin-microbiota-expert-if-you-wake-up-at-8-on-weekdays-and-at-noon-on-weekends-it-takes-3-days-to-reset-your-circadian-rhythm-30393\/\">Sara Marin, microbiota expert: &#8216;If you wake up at 8 on weekdays and at noon on weekends, it takes 3 days to reset your circadian rhythm&#8217;<\/a><\/h3>\n<\/div>\n<\/div><\/div>\n<\/div>\n\n\n\n<p class=\"wp-block-paragraph\">But none of that proves there is some special set of \u201csilence neurons\u201d out there cleaning brain tissue.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What brain cleaning actually means<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">When people talk about &#8220;cleaning the brain\u201d,they are usually referring to something called the <a href=\"https:\/\/www.science.org\/doi\/10.1126\/science.1241224\" target=\"_blank\" rel=\"noopener\">glymphatic system<\/a>. Think of it as a kind of drainage network made of fluid. This helps flush out waste away from brain tissue. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Most research has focused on sleep, anesthesia, blood-vessel rhythms, and the movement of cerebrospinal fluid, not ordinary daytime silence.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Even in that area, science is still figuring things out. A 2024 mouse study found that this waste-clearing process slowed down during sleep and anesthesia.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Meanwhile, a 2026 study involving 39 people found patterns consistent with greater overnight removal of <a href=\"https:\/\/okdiario.com\/metabolic\/en\/health\/scientists-may-have-foundy-a-simple-blood-test-that-spots-alzheimers-years-before-symptoms-appear-something-which-could-change-everything-for-your-family-29260\/\">amyloid and tau proteins<\/a> during normal sleep than during sleep deprivation.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">So what does all this actually tell us about sitting for three minutes at lunchtime? Honestly, not much, at least not yet. None of the research cited here has shown that a short quiet break while you are awake activates glymphatic clearance or removes harmful proteins from a human brain.<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"1800\" height=\"1013\" src=\"https:\/\/okdiario.com\/metabolic\/en\/wp-content\/uploads\/2026\/08\/nazareth-castellanos-neuroscientist-silence-brain-health.jpg\" alt=\"A person sitting in a quiet, peaceful space, representing neuroscience research on silence, brain health, and nervous system relaxation.\" class=\"wp-image-30407\" srcset=\"https:\/\/okdiario.com\/metabolic\/en\/wp-content\/uploads\/2026\/08\/nazareth-castellanos-neuroscientist-silence-brain-health.jpg 1800w, https:\/\/okdiario.com\/metabolic\/en\/wp-content\/uploads\/2026\/08\/nazareth-castellanos-neuroscientist-silence-brain-health-300x169.jpg 300w, https:\/\/okdiario.com\/metabolic\/en\/wp-content\/uploads\/2026\/08\/nazareth-castellanos-neuroscientist-silence-brain-health-768x432.jpg 768w, https:\/\/okdiario.com\/metabolic\/en\/wp-content\/uploads\/2026\/08\/nazareth-castellanos-neuroscientist-silence-brain-health-1536x864.jpg 1536w, https:\/\/okdiario.com\/metabolic\/en\/wp-content\/uploads\/2026\/08\/nazareth-castellanos-neuroscientist-silence-brain-health-150x84.jpg 150w\" sizes=\"auto, (max-width: 1800px) 100vw, 1800px\" \/><figcaption class=\"wp-element-caption\">Neuroscientist Nazareth Castellanos discusses how quiet moments help calm the nervous system, though research shows the biological effects are nuanced.<\/figcaption><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">Two quiet minutes can still matter<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">That said, there is better human evidence for a modest, immediate calming effect. In a study of 24 healthy young adults, researchers played different styles of music and inserted two-minute silent pauses. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">And what happened? During those pauses, heart rate, blood pressure, and breathing fell, which was consistent with <a href=\"https:\/\/okdiario.com\/metabolic\/en\/psychology\/polo-guerrero-physician-on-falling-asleep-fast-the-4-7-8-breathing-technique-helps-reduce-anxiety-and-induces-sleep-29481\/\">short-term relaxation<\/a>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">That does not make silence some kind of treatment, though. The study was small; it only looked at immediate physical reactions, and it never showed that quiet time daily prevents anxiety, depression, dementia, or other illnesses. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Still, when traffic, conversations, and <a href=\"https:\/\/okdiario.com\/metabolic\/en\/psychology\/psychology-suggests-that-people-who-continue-to-use-a-paper-planner-or-calendar-arent-necessarily-less-tech-savvy-rather-they-often-rely-on-a-more-practical-and-deliberate-way-of-organizing-27324\/\">notifications<\/a> keep tugging at attention, a pause can feel like taking your foot off the accelerator.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">A practical low-stimulation break<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">In practice, the idea here is simple: find two or three minutes during the day, close the eyes, reduce sound, and limit interaction with the surroundings. A gentler label may be \u201clow-stimulation break,\u201d since true sensory deprivation usually means a much more controlled setting.<\/p>\n\n\n\n<div class=\"gb-element-10d39234\">\n<div><div class=\"gb-looper-f8ee2f7f\">\n<div class=\"gb-loop-item gb-loop-item-841a20de post-30387 post type-post status-publish format-standard has-post-thumbnail hentry category-sports resize-featured-image\">\n<h3 class=\"gb-text gb-text-943ae805\">Read More: <a href=\"https:\/\/okdiario.com\/metabolic\/en\/sports\/neither-cycling-nor-walking-is-the-ideal-exercise-for-your-heart-doctors-say-the-real-answer-works-your-whole-body-at-once-30387\/\">Neither cycling nor walking is the ideal exercise for your heart, doctors say, the real answer works your whole body at once.<\/a><\/h3>\n<\/div>\n<\/div><\/div>\n<\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Put your phone on mute, step away from the TV playing in the background, and find somewhere safe to sit. You do not need to force your mind to go blank. The realistic aim is simply to cut down on incoming situations for a moment, not to run your brain through some kind of biological car wash.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Silence obviously cannot replace <a href=\"https:\/\/okdiario.com\/metabolic\/en\/nutrition\/losing-just-ninety-minutes-of-sleep-a-night-could-quietly-nudge-your-body-toward-weight-gain-a-columbia-university-study-found-29307\/\">real sleep<\/a>, medical care, or therapy when those are actually needed. But as a small daily habit, it really might help your body slow down and give attention a short breather. And that is genuinely useful on its own, without needing to turn one interesting study into some kind of a miracle claim.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The main study was published in<a href=\"https:\/\/link.springer.com\/article\/10.1007\/s00429-013-0679-3\" target=\"_blank\" rel=\"noopener\"> <em>Brain Structure and Function<\/em><\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Traffic outside your window, a phone buzzing on the table, music playing in the kitchen, another video autoplaying before the &#8230; <\/p>\n<p class=\"read-more-container\"><a title=\"Nazareth Castellanos, neuroscientist: the neurons that activate in silence help clean the brain, calm the nervous system and bring the mind back to balance\" class=\"read-more button\" href=\"https:\/\/okdiario.com\/metabolic\/en\/psychology\/nazareth-castellanos-neuroscientist-the-neurons-that-activate-in-silence-help-clean-the-brain-calm-the-nervous-system-and-bring-the-mind-back-to-balance-30404\/#more-30404\" aria-label=\"Read more about Nazareth Castellanos, neuroscientist: the neurons that activate in silence help clean the brain, calm the nervous system and bring the mind back to balance\">Read more<\/a><\/p>\n","protected":false},"author":18,"featured_media":30405,"comment_status":"open","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[19],"tags":[],"class_list":["post-30404","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-psychology","resize-featured-image"],"_links":{"self":[{"href":"https:\/\/okdiario.com\/metabolic\/en\/wp-json\/wp\/v2\/posts\/30404","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/okdiario.com\/metabolic\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/okdiario.com\/metabolic\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/okdiario.com\/metabolic\/en\/wp-json\/wp\/v2\/users\/18"}],"replies":[{"embeddable":true,"href":"https:\/\/okdiario.com\/metabolic\/en\/wp-json\/wp\/v2\/comments?post=30404"}],"version-history":[{"count":1,"href":"https:\/\/okdiario.com\/metabolic\/en\/wp-json\/wp\/v2\/posts\/30404\/revisions"}],"predecessor-version":[{"id":30408,"href":"https:\/\/okdiario.com\/metabolic\/en\/wp-json\/wp\/v2\/posts\/30404\/revisions\/30408"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/okdiario.com\/metabolic\/en\/wp-json\/wp\/v2\/media\/30405"}],"wp:attachment":[{"href":"https:\/\/okdiario.com\/metabolic\/en\/wp-json\/wp\/v2\/media?parent=30404"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/okdiario.com\/metabolic\/en\/wp-json\/wp\/v2\/categories?post=30404"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/okdiario.com\/metabolic\/en\/wp-json\/wp\/v2\/tags?post=30404"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}